Michael D Briggs Selected Research

Cartilage Oligomeric Matrix Protein

1/2015	Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth.
11/2014	Genotype to phenotype correlations in cartilage oligomeric matrix protein associated chondrodysplasias.
1/2014	Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia.
1/2012	Pseudoachondroplasia and multiple epiphyseal dysplasia: a 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution.
1/2012	A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.
1/2010	A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia.
9/2007	Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP.
2/2007	Preselection of cases through expert clinical and radiological review significantly increases mutation detection rate in multiple epiphyseal dysplasia.
6/2005	Novel and recurrent mutations in the C-terminal domain of COMP cluster in two distinct regions and result in a spectrum of phenotypes within the pseudoachondroplasia -- multiple epiphyseal dysplasia disease group.
5/2005	COMP mutation screening as an aid for the clinical diagnosis and counselling of patients with a suspected diagnosis of pseudoachondroplasia or multiple epiphyseal dysplasia.

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Michael D Briggs Research Topics

Disease

15	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 01/2023 - 06/2005
12	Pseudoachondroplasia 01/2015 - 05/2002
6	Dwarfism 01/2023 - 07/2007
6	Osteoarthritis 01/2014 - 07/2007
2	Muscular Diseases (Myopathy) 04/2010 - 01/2010
1	Seizures (Absence Seizure) 10/2017
1	Disease Progression 10/2015
1	Joint Instability (Joint Laxity) 12/2011
1	Osteochondritis Dissecans 04/2010
1	Aggrecan Type Spondyloepimetaphyseal Dysplasia 01/2009
1	Bone Diseases (Bone Disease) 11/2007

Drug/Important Bio-Agent (IBA)

12	Matrilin ProteinsIBA 01/2023 - 05/2002
11	Cartilage Oligomeric Matrix ProteinIBA 01/2015 - 05/2002
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 11/2010
4	CollagenIBA 10/2017 - 01/2010
3	Collagen Type IXIBA 01/2012 - 05/2002
2	Collagen Type XIBA 10/2017 - 10/2009
1	Carbamazepine (Tegretol)FDA LinkGeneric 10/2017
1	Mutant Proteins (Protein, Mutant)IBA 10/2017
1	Biomarkers (Surrogate Marker)IBA 10/2015
1	KinesinsIBA 12/2011
1	Glycoproteins (Glycoprotein)IBA 01/2010
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2010
1	Aggrecans (Aggrecan)IBA 01/2009
1	C-Type Lectins (C-Type Lectin)IBA 01/2009